Ok, here's a thought I had today - tell me if it's too crazy or just impossible. I've been wanting to build something small and cheap for guitar, like a mono tube headphone guitar amp.
I have been thinking about this exact thing. The Quickie didn't come to mind first, but I was wondering about maybe a mono version of the SEX, but with a more typical 12ax7 input. Ken Fischer of Trainwreck amps has written about adding a single 12ax7 stage for gain. Basically using 100K plate load, 1.5K cathode with 22uf cap across it, a .022uf coupling cap from the plate into a voltage divider then into the next stage. Maybe somehow you could run this into the 6DN7 output stage. Or maybe something like using a single 12dw7/7247, use the 12ax7 as the input and use the 12au7 triode to drive the 6DN7.
But a modified Quickie would be much cheaper.
Not a real expert on how to design amps or do all of the math, but I am trying to learn.